Effect of nystatin on the cytoplasmic membrane of Candida cells

  • Nystatin molecules are to be found on the surface of a yeast cell
  • Nystatin molecules penetrate the cell wall
  • Individual nystatin molecules bind to ergosterol in the cytoplasmic membrane
  • Several nystatin molecules form complexes in the cytoplasmic membrane, pore formation takes place
  • At low nystatin concentrations permeability of the membrane for ions an small molecules abnormally increases
  • At higher nystatin concentrations irreversible loss of cytoplasmic constituents, the yeast cell dies

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