Effect of nystatin on the cytoplasmic membrane of Candida cells
- Nystatin molecules are to be found on the surface of a yeast cell
- Nystatin molecules penetrate the cell wall
- Individual nystatin molecules bind to ergosterol in the cytoplasmic membrane
- Several nystatin molecules form complexes in the cytoplasmic membrane, pore formation takes place
- At low nystatin concentrations permeability of the membrane for ions an small molecules abnormally increases
- At higher nystatin concentrations irreversible loss of cytoplasmic constituents, the yeast cell dies
